Educational reference only · Not medical advice · Always consult a qualified healthcare professional
Wild Lettuce

Lactuca virosa

Wild Lettuce

Asteraceae

Evidence: InsufficientCaffeine Free Europe / MediterraneanSleep TraditionsPain TraditionsRelaxation
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Identity

Common Name
Wild Lettuce
Scientific Name
Lactuca virosa
Botanical Family
Asteraceae
Native Region
Europe and the Mediterranean
Cultivation Regions
Europe, North Africa, temperate regions
Plant Parts Used
Leaves, Milky latex (lactucarium)
Synonyms
Bitter Lettuce, Lactucarium, Opium Lettuce
Caffeine Level
Caffeine Free

A tall biennial with large lobed blue-green leaves clasping a hollow stem that exudes a milky latex, and a loose pyramidal cluster of small pale-yellow composite flowers; the leaves and latex are used.

Historical Background

Wild lettuce has been a European and Mediterranean folk sedative for centuries, its milky latex ('lactucarium') prized as 'lettuce opium' for pain and sleep. The leaves brew a mild, calming, caffeine-free cup, while the concentrated latex is far stronger and historically used cautiously.

Earliest recorded uses: European and Mediterranean traditions for centuries; a mild sedative and pain herb ('lettuce opium').

Traditional preparations:

  • Leaf infusion
  • Calming evening tea
  • Practitioner-guided latex use

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

European Folk Traditions

Mild folk sedative and pain herb.

Modern Herbalism

Calming caffeine-free cup (leaves only).

Flavor & Aroma

MildGreenSlightly BitterMilky

Aroma: Mild, green, slightly bitter, milky

Tea Information

Suitable for Tea
Yes
Preparation Methods
Infusion (leaves), Practitioner-guided use
Steeping Temperature
200 F (93 C)
Steeping Time
5-8 minutes
Recommended Vessel
Teapot
Blends Well With
Valerian, Lemon Balm, Honey, Passionflower, Chamomile
200 F (93 C) 5-8 minutes

Safety & Cautions

Contraindications
Generally safe in small food/tea amounts but the dried latex is a strong sedative - avoid in pregnancy, breastfeeding, children, and with sedatives; avoid in glaucoma, enlarged prostate, and before driving; discontinue before surgery.
Drug Interactions
May enhance sedatives, opioids, and CNS depressants - avoid combinations; may lower blood pressure - consult a clinician.
Pregnancy
Avoid; sedative latex compounds and limited safety data.
Breastfeeding
Avoid; sedative compounds pass into milk.
Children
Not recommended for use by children; sedative compounds with limited safety data.
Allergies
Possible in those sensitive to Asteraceae; may cross-react with daisy/lettuce family.
Known Adverse Effects
May cause drowsiness or mild sedation at higher doses; high doses may cause GI upset, anxiety, or rapid heart rate; concentrated latex is a strong sedative - use sparingly and with caution.

Research Summary

Evidence Level: Insufficient

Wild lettuce has a tradition as a mild sedative and pain herb; preclinical work suggests sedative activity from lactucarium (lactucin). Clinical evidence is insufficient; it is not a treatment for insomnia, pain, anxiety, or any disease, and its concentrated latex warrants cautious, practitioner-guided use.

Evidence levels reflect the currently available scientific literature and may change as new research emerges. Where evidence is limited or conflicting, this is stated plainly.

References & Sources

References & Sources

  1. EMA HMPC · Lactucae assessment (2015)
  2. PubMed · Lactuca virosa review (2019)

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Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

© 2026 Soothing Brews · For educational purposes only.

Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane