Educational reference only · Not medical advice
Botanical illustration of Wild Lettuce

Lactuca virosa

Wild Lettuce

Asteraceae

Evidence: InsufficientCaffeine Free Europe / MediterraneanSafety information on file
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At a Glance

Common name
Wild Lettuce
Scientific name
Lactuca virosa
Family
Asteraceae
Region
Europe / Mediterranean
Plant part
Leaves, Milky latex (lactucarium)
Caffeine
Caffeine Free
Evidence
Insufficient
Safety review
Safety information on file

Safety & Cautions

Safety information on file
Contraindications
Generally safe in small food/tea amounts but the dried latex is a strong sedative - avoid in pregnancy, breastfeeding, children, and with sedatives; avoid in glaucoma, enlarged prostate, and before driving; discontinue before surgery.
Drug interactions
May enhance sedatives, opioids, and CNS depressants - avoid combinations; may lower blood pressure - consult a clinician.
Pregnancy
Avoid; sedative latex compounds and limited safety data.
Breastfeeding
Avoid; sedative compounds pass into milk.
Children
Not recommended for use by children; sedative compounds with limited safety data.
Allergies
Possible in those sensitive to Asteraceae; may cross-react with daisy/lettuce family.
Known adverse effects
May cause drowsiness or mild sedation at higher doses; high doses may cause GI upset, anxiety, or rapid heart rate; concentrated latex is a strong sedative - use sparingly and with caution.

Botanical Description

A tall biennial with large lobed blue-green leaves clasping a hollow stem that exudes a milky latex, and a loose pyramidal cluster of small pale-yellow composite flowers; the leaves and latex are used.

Also known as: Bitter Lettuce, Lactucarium, Opium Lettuce

Historical Background

Wild lettuce has been a European and Mediterranean folk sedative for centuries, its milky latex ('lactucarium') prized as 'lettuce opium' for pain and sleep. The leaves brew a mild, calming, caffeine-free cup, while the concentrated latex is far stronger and historically used cautiously.

Earliest recorded uses: European and Mediterranean traditions for centuries; a mild sedative and pain herb ('lettuce opium').

Traditional preparations:

  • Leaf infusion
  • Calming evening tea
  • Practitioner-guided latex use

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

European Folk Traditions

Mild folk sedative and pain herb.

Modern Herbalism

Calming caffeine-free cup (leaves only).

Flavor & Aroma

MildGreenSlightly BitterMilky

Aroma: Mild, green, slightly bitter, milky

Tea Preparation

Preparation methods
Infusion (leaves), Practitioner-guided use
Steeping temperature
200 F (93 C)
Steeping time
5-8 minutes
Recommended vessel
Teapot
Blends well with
Valerian, Lemon Balm, Honey, Passionflower, Chamomile
200 F (93 C) 5-8 minutes

Modern Evidence

Evidence level: Insufficient

Wild lettuce has a tradition as a mild sedative and pain herb; preclinical work suggests sedative activity from lactucarium (lactucin). Clinical evidence is insufficient; it is not a treatment for insomnia, pain, anxiety, or any disease, and its concentrated latex warrants cautious, practitioner-guided use.

Evidence levels describe the state of research for the traditional use discussed here, not a recommendation. Historical use does not imply effectiveness.

References & Sources

  1. EMA HMPC · Lactucae assessment (2015)
  2. PubMed · Lactuca virosa review (2019)

Entry last updated August 4, 2026

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

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Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane