Educational reference only · Not medical advice
Botanical illustration of Seville Orange

Citrus aurantium

Seville Orange

Rutaceae

Evidence: LimitedCaffeine Free (but synephrine is stimulant) Mediterranean / AsiaSafety information on file
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At a Glance

Common name
Seville Orange
Scientific name
Citrus aurantium
Family
Rutaceae
Region
Mediterranean / Asia
Plant part
Peel, Flowers (neroli), Leaves
Caffeine
Caffeine Free (but synephrine is stimulant)
Evidence
Limited
Safety review
Safety information on file

Safety & Cautions

Safety information on file
Contraindications
Contains synephrine - avoid with hypertension, heart disease, arrhythmia, glaucoma, and with MAOIs, caffeine, and stimulants; avoid medicinal doses in pregnancy; limit in anxiety and insomnia; discontinue before surgery.
Drug interactions
Synephrine interacts with MAOIs, caffeine, decongestants, blood-pressure, and heart medications - consult a clinician.
Pregnancy
Avoid medicinal doses; synephrine stimulant - consult a clinician.
Breastfeeding
Avoid medicinal doses; synephrine stimulant - consult a clinician.
Children
Not recommended for regular use by children; synephrine stimulant.
Allergies
Possible in those sensitive to Rutaceae; citrus allergy possible.
Known adverse effects
May cause jitteriness, anxiety, palpitations, headache, insomnia, or elevated blood pressure from synephrine; high doses may affect heart rhythm; rare allergic reactions.

Botanical Description

An evergreen tree with glossy ovate leaves, fragrant white orange-blossom flowers, and a round bumpy orange fruit; the leaves, flowers (neroli), and peel are used.

Also known as: Bitter Orange, Sour Orange, Zhi Shi

Historical Background

Seville (bitter) orange has been a Mediterranean and Asian treasure for centuries, its sour fruit prized for marmalade, its fragrant blossom distilled into neroli, and its leaves and peel brewed into a bitter digestive tea. Traditional Chinese practice uses the immature fruit (zhi shi) for digestion.

Earliest recorded uses: Mediterranean and Asian traditions for centuries; a bitter orange for peel, blossom (neroli), and leaf.

Traditional preparations:

  • Peel decoction
  • Neroli blossom infusion
  • Bitter digestive tea

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Chinese Traditions

Bitter digestive peel (zhi shi) and neroli blossom.

Mediterranean Traditions

Bitter digestive and aromatic cup.

Flavor & Aroma

CitrusBitter-orangeFloralSlightly Spicy

Aroma: Citrus, bitter-orange, floral, slightly spicy

Tea Preparation

Preparation methods
Peel decoction, Blossom infusion (neroli), Leaf tea
Steeping temperature
200 F (93 C)
Steeping time
5-8 minutes
Recommended vessel
Teapot or saucepan
Blends well with
Green Tea, Mint, Ginger, Honey, Rose Hips
200 F (93 C) 5-8 minutes

Modern Evidence

Evidence level: Limited

Seville orange has a tradition as a bitter digestive, and its blossom (neroli) as a calming aroma; the peel contains synephrine, a stimulant with cardiovascular concerns at high doses. Clinical evidence is mixed; it is not a treatment for obesity, indigestion, anxiety, or any disease, and stimulant-containing products warrant caution.

Evidence levels describe the state of research for the traditional use discussed here, not a recommendation. Historical use does not imply effectiveness.

References & Sources

  1. EMA HMPC · Aurantii pericarpium monograph (2014)
  2. PubMed · Citrus aurantium synephrine review (2019)

Entry last updated August 4, 2026

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

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Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane