Educational reference only · Not medical advice · Always consult a qualified healthcare professional
Oregon Grape

Mahonia aquifolium

Oregon Grape

Berberidaceae

Evidence: LimitedCaffeine Free Pacific NorthwestLiver & Detox TraditionsSkin & Healing TraditionsImmune Traditions
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Identity

Common Name
Oregon Grape
Scientific Name
Mahonia aquifolium
Botanical Family
Berberidaceae
Native Region
Western North America
Cultivation Regions
Pacific Northwest, western North America
Plant Parts Used
Root, Root bark
Synonyms
Oregon Grape Holly, Mountain Grape, Holly-Leaved Barberry
Caffeine Level
Caffeine Free

An evergreen shrub with glossy spiny holly-like pinnate green leaves, clusters of small bright yellow flowers, and dangling clusters of round blue-purple grape-like berries; the root and root bark are used (sometimes the leaf).

Historical Background

Oregon grape has been an Indigenous Pacific Northwest medicine for centuries, its bright yellow berberine-rich root used much like goldenseal for skin, liver, and infection. A sustainable native alternative to goldenseal, it remains a potent, bitter, practitioner-guided herb.

Earliest recorded uses: Indigenous Pacific Northwest traditions for centuries; a bitter yellow root for skin, liver, and infection.

Traditional preparations:

  • Small-dose root infusion
  • Bitter liver and skin tea
  • Practitioner-guided use

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Indigenous North American Traditions

Bitter yellow root for skin, liver, and infection.

Modern Herbalism

Sustainable goldenseal alternative (short-term).

Flavor & Aroma

BitterTartSlightly FruityEarthy

Aroma: Bitter, tart, slightly fruity, earthy

Tea Information

Suitable for Tea
Yes
Preparation Methods
Infusion (small dose), Practitioner-guided use
Steeping Temperature
200 F (93 C)
Steeping Time
5-7 minutes
Recommended Vessel
Teapot
Blends Well With
Goldenseal, Echinacea, Honey, Ginger, Yarrow
200 F (93 C) 5-7 minutes

Safety & Cautions

Contraindications
Avoid in pregnancy and breastfeeding (berberine); avoid with blood-pressure, blood-sugar, and sedative medications; overuse discouraged; discontinue before surgery.
Drug Interactions
Berberine affects CYP enzymes and blood-pressure/blood-sugar/sedative drugs - consult a clinician before use.
Pregnancy
Avoid; berberine may stimulate the uterus.
Breastfeeding
Avoid; berberine unsafe for neonates.
Children
Not recommended for regular use by children; berberine compounds.
Allergies
Possible in those sensitive to Berberidaceae; rare.
Known Adverse Effects
Generally well tolerated in small amounts; high doses may cause GI upset or low blood sugar; rare allergic reactions.

Research Summary

Evidence Level: Limited

Oregon grape has a tradition as a bitter liver, skin, and antimicrobial root; berberine shows antimicrobial and anti-inflammatory activity in vitro, and some topical use for psoriasis. Clinical evidence for internal tea is limited; it is not a treatment for psoriasis, liver disease, infection, or any disease, and its strong alkaloids warrant short-term, cautious use.

Evidence levels reflect the currently available scientific literature and may change as new research emerges. Where evidence is limited or conflicting, this is stated plainly.

References & Sources

References & Sources

  1. EMA HMPC · Mahoniae radix assessment (2015)
  2. PubMed · Mahonia aquifolium review (2019)

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Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

© 2026 Soothing Brews · For educational purposes only.

Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane