Educational reference only · Not medical advice
Botanical illustration of Guayusa

Ilex guayusa

Guayusa

Aquifoliaceae

Evidence: InsufficientCaffeinated (high) South AmericaSafety information on file
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At a Glance

Common name
Guayusa
Scientific name
Ilex guayusa
Family
Aquifoliaceae
Region
South America
Plant part
Leaves
Caffeine
Caffeinated (high)
Evidence
Insufficient
Safety review
Safety information on file

Safety & Cautions

Safety information on file
Contraindications
Avoid excess in pregnancy, cardiovascular sensitivity, anxiety, and GERD; caffeine-sensitive caution; discontinue before surgery.
Drug interactions
Caffeine interacts with stimulants, theophylline, MAO inhibitors, and certain heart/blood pressure medications; consult a clinician.
Pregnancy
Limit caffeine intake.
Children
Not recommended for children (caffeine content).
Allergies
Possible in those sensitive to Aquifoliaceae; rare.
Known adverse effects
Caffeine-related effects: jitteriness, insomnia, palpitations, acid reflux; very high caffeine — moderate intake advised.

Botanical Description

An evergreen holly tree of the Amazon with large glossy oval serrated leaves and small white clustered flowers; the dried leaves are prepared as a traditional caffeinated Amazonian infusion, richer and less bitter than mate.

Also known as: Wayusa, Holly Leaf

Historical Background

Guayusa has been a sacred dawn tea of the Kichwa peoples of the Ecuadorian Amazon for centuries, shared around morning fires to sharpen focus, share dreams, and build community. Its smooth, naturally sweet, high-caffeine leaves make it a gentler cousin to yerba mate.

Earliest recorded uses: Indigenous Kichwa (Quechua) Amazonian traditions for centuries; a sacred dawn ritual tea.

Traditional preparations:

  • Leaf infusion
  • Dawn ritual tea
  • Iced guayusa

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Indigenous Amazonian Traditions

Sacred dawn tea for focus, dreams, and community.

Modern Herbalism

Smooth caffeinated focus tea.

Flavor & Aroma

SmoothSlightly SweetEarthyGrassy

Aroma: Smooth, slightly sweet, earthy, grassy

Tea Preparation

Preparation methods
Infusion
Steeping temperature
185°F (85°C)
Steeping time
5-7 minutes (re-steepable)
Recommended vessel
Teapot or gourd
Blends well with
Green Tea, Yerba Mate, Lemon, Mint, Cinnamon
185°F (85°C) 5-7 minutes (re-steepable)

Modern Evidence

Evidence level: Insufficient

Guayusa is a traditional high-caffeine Amazonian stimulant tea rich in antioxidants. Clinical evidence is insufficient; it is not a treatment for fatigue, obesity, or any disease; moderate intake is advised given caffeine content.

Evidence levels describe the state of research for the traditional use discussed here, not a recommendation. Historical use does not imply effectiveness.

References & Sources

  1. PubMed · Ilex guayusa review (2019)
  2. EMA HMPC · Ilex guayusa assessment (2017)

Entry last updated August 4, 2026

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

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Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane