Educational reference only · Not medical advice

Paullinia cupana

Guarana

Sapindaceae

Evidence: ModerateHigh Amazon, BrazilSafety information on file
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At a Glance

Common name
Guarana
Scientific name
Paullinia cupana
Family
Sapindaceae
Region
Amazon, Brazil
Plant part
Seed
Caffeine
High
Evidence
Moderate
Safety review
Safety information on file

Safety & Cautions

Safety information on file
Contraindications
Avoid in caffeine sensitivity, hypertension, heart conditions, anxiety, and seizure disorders.
Drug interactions
Interacts with stimulants, theophylline, MAOIs, and drugs metabolized by CYP1A2.
Pregnancy
Limit caffeine; consult a professional before use in pregnancy.
Breastfeeding
Limit use due to caffeine transfer to milk.
Children
Not recommended for children.
Allergies
Rare.
Known adverse effects
May cause insomnia, anxiety, palpitations, or stomach upset at higher doses.

Botanical Description

An Amazonian seed containing high levels of caffeine, traditionally used to sustain energy and alertness.

A climbing woody vine with compound leaves and pear-shaped red capsules that split open to reveal black seeds partly covered by white arils, resembling eyes.

Historical Background

Cultivated for centuries by Indigenous Amazonian peoples, notably the Sateré-Mawé, who regard guarana as a sacred plant. It spread into Brazilian soft drinks and global supplements.

Earliest recorded uses: Documented by Jesuit missionaries in the 17th century, though Indigenous use predates colonization.

Cultural significance: Central to Sateré-Mawé origin mythology; traditionally ground into a stick and grated into drinks.

Traditional preparations:

  • Seeds roasted and ground into a paste stick, then grated into water
  • Powdered seed infusion

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Indigenous Amazonian

Used to relieve fatigue, suppress hunger, and treat diarrhea.

Brazilian folk medicine

Employed as a stimulant tonic and headache remedy.

Flavor & Aroma

BitterEarthyAstringent

Aroma: Toasted, earthy

Tea Preparation

Preparation methods
Stir 0.5 to 1 gram of powder into hot (not boiling) water; steep 5 minutes
Steeping temperature
90°C (194°F)
Steeping time
5 to 8 minutes
Recommended vessel
Small ceramic cup
Blends well with
Cacao, Yerba mate, Green tea, Vanilla
90°C (194°F) 5 to 8 minutes

Modern Evidence

Evidence level: Moderate

Effects are largely due to caffeine with related alkaloids; some trials suggest benefits for cognitive performance and fatigue, though evidence is mixed.

Evidence levels describe the state of research for the traditional use discussed here, not a recommendation. Historical use does not imply effectiveness.

References & Sources

  1. NIH ODS · Caffeine (2023)
  2. PubMed · Guarana for cognitive and energy outcomes: review (2021)

Entry last updated August 29, 2026

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

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Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane