Educational reference only · Not medical advice
Botanical illustration of Comfrey

Symphytum officinale

Comfrey

Boraginaceae

Evidence: InsufficientCaffeine Free EuropeSafety information on file
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At a Glance

Common name
Comfrey
Scientific name
Symphytum officinale
Family
Boraginaceae
Region
Europe
Plant part
Leaves, Root (topical mainly)
Caffeine
Caffeine Free
Evidence
Insufficient
Safety review
Safety information on file

Safety & Cautions

Safety information on file
Contraindications
Avoid internal use (PAs harm the liver); restrict to short-term topical use on intact skin; avoid in pregnancy, breastfeeding, liver disease, and with anticoagulants; discontinue before surgery.
Drug interactions
PAs may strain the liver and interact with liver-metabolized drugs; may enhance bleeding with anticoagulants; consult a clinician.
Pregnancy
Avoid.
Children
Not recommended for children (PA content).
Allergies
Possible in those sensitive to Boraginaceae; rare contact dermatitis.
Known adverse effects
The leaves and roots contain pyrrolizidine alkaloids (PAs) that can harm the liver — oral/internal use is restricted in many countries; topical use is traditional but avoid broken skin; do not take internally long-term.

Botanical Description

A large coarse perennial with broad lance-shaped hairy dark green leaves on winged stems and drooping clusters of small tubular bell-shaped flowers that are purple-blue to pinkish-cream; the leaves and roots are the part used.

Also known as: Knit-Bone, Boneset, Bruisewort

Historical Background

Comfrey ('knit-bone') has been a revered European folk wound and skin herb for millennia, its large leaves and roots applied traditionally to bruises and sprains. Internal use is now restricted in many countries due to liver-harming pyrrolizidine alkaloids (PAs), so it is best limited to short-term topical use.

Earliest recorded uses: European folk traditions for millennia; a classic 'knit-bone' wound and skin herb.

Traditional preparations:

  • Topical leaf poultice
  • Root compress (external)
  • Skin salve base

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Traditional European Herbalism

'Knit-bone' wound and skin herb (topical).

Modern Herbalism

Traditional skin herb (internal use restricted).

Flavor & Aroma

MildSlightly Cucumber-likeGreenEarthy

Aroma: Mild, slightly cucumber-like, green, earthy

Tea Preparation

This herb is not typically prepared as a tea or infusion.

Modern Evidence

Evidence level: Insufficient

Comfrey has a long tradition as a wound and skin herb, but its pyrrolizidine alkaloids (PAs) can cause serious liver injury, so oral/internal use is restricted in many countries. It is not a treatment for wounds, sprains, or any condition; restrict to short-term topical use on intact skin and consult a clinician.

Evidence levels describe the state of research for the traditional use discussed here, not a recommendation. Historical use does not imply effectiveness.

References & Sources

  1. EMA HMPC · Symphyti restriction (2015)
  2. FDA · Comfrey PA advisory (2001)

Entry last updated August 4, 2026

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

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Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane