Educational reference only · Not medical advice · Always consult a qualified healthcare professional
Boneset

Eupatorium perfoliatum

Boneset

Asteraceae

Evidence: InsufficientCaffeine Free North AmericaCold SeasonSeasonal WellnessImmune Traditions
Save to favorites

Identity

Common Name
Boneset
Scientific Name
Eupatorium perfoliatum
Botanical Family
Asteraceae
Native Region
Eastern North America
Cultivation Regions
North America, Europe (ornamental)
Plant Parts Used
Leaves and flowering tops
Synonyms
Thoroughwort, Ague Weed, Feverwort, Sweating Plant
Caffeine Level
Caffeine Free

A tall native American perennial whose pairs of opposite lance-shaped leaves appear to be pierced (perfoliate) by the stout stem. Crowns of small, fuzzy white flowers bloom in late summer.

Historical Background

A signature remedy of 19th-century American Eclectic and Thomsonian practice for the fevers and bone-aching chills of influenza and malaria ('ague'). The name 'boneset' refers to the deep aching it was used to relieve.

Earliest recorded uses: Inducing sweating to break fevers, relieving the bone-ache of influenza, and as a bitter digestive tonic.

Cultural significance: Among the most-used Native American febrifuges adopted by settlers; long listed in the United States Pharmacopeia.

  1. Indigenous

    Native American groups use boneset for fevers and colds.

  2. 19th century

    A mainstay of Eclectic and Thomsonian practice for 'ague' and influenza.

  3. 20th century

    Declines as quinine and modern antipyretics displace it.

Traditional preparations:

  • Warm infusion (very bitter)
  • Cold infusion (less nauseating)

Traditional Uses

These uses document historical traditions and do not imply proven effectiveness.

Native American Traditions

Infusion drunk warm to promote sweating and ease the aching of fever.

Traditional European Herbalism (adopted)

Adopted by settlers as a diaphoretic and bitter tonic.

Flavor & Aroma

Very bitterAstringentEarthy

Aroma: Faint, pungent and hay-like

Tea Information

Suitable for Tea
Yes
Preparation Methods
Infusion, Cold maceration
Steeping Temperature
200°F (93°C)
Steeping Time
10-15 minutes
Recommended Vessel
Standard teapot
Blends Well With
Peppermint, Elderflower, Ginger, Honey
200°F (93°C) 10-15 minutes

Safety & Cautions

Contraindications
Avoid in pregnancy and breastfeeding. Avoid with ragweed/Compositae allergy. Not for long-term use.
Drug Interactions
No well-characterized interactions; theoretical caution with hepatotoxic co-medications.
Pregnancy
Avoid — traditional emmenagogue and theoretical hepatorenal concerns.
Breastfeeding
Avoid; insufficient safety data.
Children
Traditional short-term use only at reduced strength; not recommended without professional guidance.
Allergies
Cross-reactivity possible in ragweed allergy sufferers (Compositae family).
Known Adverse Effects
Nausea and vomiting at full strength due to extreme bitterness; potential hepatotoxicity with prolonged high doses (some related Eupatorium species contain unsaturated pyrrolizidine alkaloids — E. perfoliatum's profile is debated; err on caution).

Research Summary

Evidence Level: Insufficient

Used almost entirely on traditional grounds; controlled trials are lacking. Pharmacological interest centers on sesquiterpene lactones, but modern evidence does not establish efficacy for fever.

Evidence levels reflect the currently available scientific literature and may change as new research emerges. Where evidence is limited or conflicting, this is stated plainly.

References & Sources

References & Sources

  1. American Botanical Council · Expanded Commission E Monographs (2000)
  2. American Herbal Products Association · Botanical Safety Handbook (2013)

Related Herbs

Soothing Brews

An educational encyclopedia preserving the history, traditions, and modern evidence behind herbs used in teas and infusions. Inspired by antique botanical manuscripts.

Steeped in tradition, grounded in honesty.

Please Note

This is an educational reference, not a medical resource. Historical use does not imply effectiveness. Natural does not always mean safe. Consult a qualified healthcare professional before using herbs, especially if pregnant, nursing, or taking medications.

© 2026 Soothing Brews · For educational purposes only.

Preferred sources: NIH ODS · NCCIH · MSK Herbs · PubMed · WHO · EMA · German Commission E · Cochrane